Updates to the Domestic Substances List

Summary#

Order 2024-66-07-01 Amending the Domestic Substances List updates which chemicals and biological organisms appear on Canada’s Domestic Substances List. The order was made under the Canadian Environmental Protection Act, 1999 and came into force on the day it was registered (September 5, 2024).

What it does#

• Removes one entry from Part 1 of the List (the item shown as 6290-03-05 N).
• Adds a group of new substance entries (many listed by CAS numbers) into Part 1.
• Deletes a set of chemical entries from Part 3 and corrects a reference number (changing “194653 N-P” to “19465-3 N-P”).
• Updates Part 5 (organisms) by removing several vaccine strains and engineered viral vectors or cells, and then re‑adding them with the annotation shown in the order (for example, the cold-adapted influenza strains and two recombinant adenovirus vaccine constructs are listed with an “N” annotation). The French version of Part 5 is updated correspondingly.
• The order is registered and therefore in force as of September 5, 2024.

Who's affected#

• Companies that make, import, sell, or use the listed chemicals (chemical manufacturers, importers, distributors).
• Laboratories, biotech and pharmaceutical firms, and research institutions that work with the listed organisms or viral vectors.
• Regulatory or compliance staff who track inventory and reporting obligations for substances in Canada.
• The general public is unlikely to notice direct effects unless they work with or are exposed to the listed substances or organisms.

If it is unclear whether a particular business or activity is affected, the Gazette item does not explain that detail.

Why it matters#

• The Domestic Substances List is Canada’s official inventory of chemicals and certain biological agents. Changes to that list change which specific substances and organisms are recorded by the government.
• For businesses and labs, being added to or removed from the List can affect how the substance is tracked and whether it shows up in government lists used for assessments, reporting or regulatory review. The Gazette notice itself does not spell out any specific downstream regulatory obligations or consequences.