Domestic Substances List: Additions and Replacements

Summary#

This is Order 2025-66-04-01 Amending the Domestic Substances List under the Canadian Environmental Protection Act, 1999. It adds several chemical entries to Part 1, removes some entries from Part 3, and replaces a number of masked names with their full chemical names. The order was registered on August 29, 2025 and comes into force on that day.

What it does#

• Adds these CAS numbers to Part 1 of the Domestic Substances List:

  • 60318-84-5
  • 146434-45-9
  • 178603-61-7
  • 178603-62-8
  • 197863-86-8
  • 219609-17-3
  • 219609-18-4
  • 221269-38-1
  • 376364-24-8

• Deletes the following entries from Part 3 of the List (CAS number followed by the listed name):

  • 11994-6 — 1,3-Isobenzofurandione, polymer with 2,2-dimethyl-1,3-propanediol, 1,2-propanediol, 1,2-ethanediol, branched alcohol, 2,5-furandione and fatty acid unsaturated dimers
  • 13642-7 — 1,3-Benzenedicarboxylic acid, polymer with 2,2-dimethyl-1,3-propanediol, fatty acid unsaturated dimers, branched alcohol, 2,6-furandione and 1,2-propanediol
  • 14550-6 — Phenol, 4,4′-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane, 2-butoxyethanol, alkanol and phosphoric acid
  • 14653-1 — 2-Propenoic acid, 2-methyl-, butyl ester, polymer with ethenylbenzene, branched aliphatic acrylate ester and 2-methyl-2-propenoic acid
  • 14986-1 — 1,3-Benzenedicarboxylic acid, polymer with 2,5-furandione, hexanedioic acid, branched diol, 2,2′-oxybis(ethanol) and 1,2-propanediol
  • 15014-2 — 2,5-Furandione, polymer with branched alcohol, 1,3-isobenzofurandione and 2-methyl-1,3-propanediol
  • 15015-3 — 2,5-Furandione, polymer with 1,2-ethanediol, branched alcohol, 1,3-isobenzofurandione, 2-methyl-1,3-propanediol and 1,2-propanediol
  • 16639-7 — Methyloxirane, polymer with oxirane, ether with 1,2,3-propanetriol (3:1), α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 1,3-diisocyanatomethylbenzene, mercaptoalkanol and ethenyltrialkoxysilane blocked
  • 16641-0 — Methyloxirane, polymer with oxirane, ether with 1,2,3-propanetriol (3:1), α-hydro-ω-hydroxypoly[oxy(methyl-1,2-ethanediyl)], 1,3-diisocyanatomethylbenzene, 3-mercaptoalkanol and ethenyltrialkoxysilane blocked

• Replaces a series of masked names in Part 3 with full chemical names (masked name → full name):

  • 11595-3 T → Dodecylbenzenesulfonic acid, compd. with iminobis[alkanol]
  • 11981-2 T-P → 2-Propenoic acid, 2-methyl-, carbomonocycle ester, polymer with 2-ethylhexyl 2-methyl-2-propenoate, 2-alkylalkyl 2-propenoate and 2-substitutedethyl 2-propenoate, tert-Bu alkaneperoxoate-initiated
  • 12332-2 T → Heteropolycycledione, polymer with 2,2-dimethyl-1,3-propanediol and 2-ethyl-2-(hydroxymethyl)-1,3-propanediol
  • 12338-8 T → 2-Propenoic acid, 2-methyl-, butyl ester, polymer with butyl 2-propenoate, ethenylbenzene and hydroxyalkyl 2-methyl-2-propenoate
  • 12658-4 T → Poly(oxy-1,4-butanediyl), α-(substituted)-ω-[(aminocarbonyl)oxy]-
  • 12916-1 T → 2-Propenoic acid, 2-methyl-, 1,1′-(1,2-ethanediyl) ester, polymer with butyl 2-propenoate, ethenylbenzene and alkyl 2-methyl-2-propenoate
  • 13045-4 N → 1,3-Benzenedimethanamine, N1,N1,N3,N3-tetrakis(2-oxiranylmethyl)-, polymer with carbomonocycledimethanamine
  • 13051-1 T-P → Carbomonocycledicarboxylic acid, polymer with dimethyl 1,4-benzenedicarboxylate, 2,2-dimethyl-1,3-propanediol, 1,2-ethanediol and 1,6-hexanediol
  • 13056-6 T-P → 2-Propenoic acid, 2-methyl-, alkyl ester, polymer with ethenylbenzene, 2-oxiranylmethyl 2-methyl-2-propenoate and 1,2-propanediol mono-2-propenoate, isooctadecanoate
  • 13411-1 N → Dodecanedioic acid, polymer with 2,2′-[1,4-butanediylbis(oxymethylene)]bis[oxirane], (chloromethyl)oxirane, 4,4′-(1-methylethylidene)bis[phenol], alkanedioic acid and 2,2′-oxybis[ethanol]
  • 13500-0 N → 2-Propenoic acid, 2-methyl-, 2-(disubstituted)ethyl ester, polymer with butyl 2-propenoate, 2-hydroxyethyl 2-propenoate and methyl 2-methyl-2-propenoate
  • 14017-4 T → Alkanoic acid, 2-hydroxy-, compd. with α-(2-aminomethylethyl)-ω-(2-aminomethylethoxy)poly[oxy(methyl-1,2-ethanediyl)] polymer with 2-(chloromethyl)oxirane and 4,4′-(1-methylethylidene)bis[phenol]
  • 14409-0 N → Non-metallic acid, polymer with 2-(chloromethyl)oxirane, 4,4′-(1-methylethylidene)bis[phenol] and 2-(phenoxymethyl)oxirane
  • 16232-5 N → Poly[oxy(methyl-1,2-ethanediyl)], α-[2-[[(2-substitutedethoxy)carbonyl]amino]methylethyl]-ω-[2-[[(2-hydroxyethoxy)carbonyl]amino]methylethoxy]-

• The order was signed by Julie Dabrusin on August 27, 2025 and was registered on August 29, 2025. It takes effect on the day of registration.

Who's affected#

• Manufacturers and importers of the specific chemicals listed above.
• Companies that supply, use, or formulate products with those chemicals (for example, plastics, coatings, adhesives or specialty chemical producers), where these chemicals appear.
• Laboratories, testing services, and consultants who track or report on substances on the Domestic Substances List.
• The general public and environmental groups may notice improved public names for certain masked substances (more transparency).

If you want to know whether a particular product or company is affected, the order lists the exact CAS numbers and chemical names; use those to check product ingredient lists or supplier safety data sheets.

Why it matters#

• The Domestic Substances List is how Canada records chemicals that are already on the market. Being listed affects whether a substance needs a new-substance review or special reporting under the Canadian Environmental Protection Act, 1999.
• Adding a substance to Part 1 generally signals it is treated as an existing substance in Canada. That can reduce the need for some new-notification steps for companies, but does not by itself say the substance is safe or unsafe.
• Removing items or replacing masked names with full names changes what is publicly visible about some chemicals. That affects transparency for communities, researchers, and downstream users who want to know what chemicals are in commerce.
• The order is administrative and specific: it updates where and how certain substances appear on the list. The Canada Gazette entry notes a related Regulatory Impact Analysis Statement is published nearby for readers seeking more detail.