Glycinamide Ministerial Condition Granted

Summary#

The Government has allowed the manufacture or import of the chemical glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)- (CAS 1448347-49-6) under Ministerial Condition No. 22632 issued under the Canadian Environmental Protection Act, 1999. The permission is limited and comes with reporting, release-response, transfer and record-keeping rules; the conditions came into force on September 14, 2026.

What it does#

• Limits manufacture or import of the substance to the person who supplied information to the government (the “notifier”) as of September 4, 2026.
• Requires the notifier to notify the Minister of the Environment at least 120 days before starting to manufacture in Canada and to provide:
  • the expected annual quantity and the manufacturing facility address;
  • details about how the substance will be transported and stored (containers, modes);
  • estimates of where and how much might be released to water, air, land and to municipal wastewater systems, and descriptions of receiving waters or land if relevant;
  • recommended methods for destruction or disposal, past and likely uses, and any factors that limit environmental exposure;
  • a description of the manufacturing process, precursors, process flow diagram and steps where releases could occur and how they will be prevented.
• If any release to the environment happens, the notifier must immediately stop further release, limit spread, and notify an enforcement officer or the province/territory’s 24-hour emergency telephone service as soon as possible.
• Before giving the substance to another person, the notifier must inform them in writing of these conditions and get written confirmation that they agree to follow them.
• Record-keeping rules require the notifier to keep records (electronic or paper) of uses, quantities manufactured/imported/purchased/distributed/sold/used, names and addresses of recipients, and the written confirmations. Records must be:
  • created within 30 days after the information becomes available;
  • kept for at least five years at the notifier’s principal place of business in Canada (or their Canadian representative);
  • in English, French, or both; and electronic records must be readable.

Who's affected#

• Primarily the notifier — the person who provided the required information to the government on September 4, 2026. They alone are allowed to manufacture or import the substance under these conditions.
• Any company or person who might receive the substance from the notifier. They must be informed of the conditions and confirm in writing that they will comply.
• Manufacturing facilities and their local communities if production starts, because the conditions require advance notice and information about potential releases.
• Regulators and emergency responders, who will be notified if releases occur and may use the records and reports to assess risk.

Why it matters#

• The measure lets limited work with a chemical that the government suspects could be harmful while keeping tighter controls and information in place.
• Requiring advance notice, process details and release-response rules aims to reduce accidental pollution and give authorities and nearby communities better information about potential risks.
• Record and transfer rules make it harder for the substance to be widely distributed without oversight, which affects companies that might consider using or selling it.
• If you live near a potential manufacturing site, work in wastewater, emergency response, or handle chemicals, these conditions affect how the substance could be introduced and monitored locally.