Non-domestic Substances List Amended

Summary#

The federal environment minister issued two orders that change the Non-domestic Substances List under the Canadian Environmental Protection Act, 1999. The main order adds a very large set of chemicals (listed by CAS number) and removes a few; it takes effect on publication in the Canada Gazette (September 20, 2025). A second, related order removes one CAS number and becomes effective when a separate Domestic Substances List order comes into force (date not stated).

What it does#

• Order 2025-66-01-02 Amending the Non-domestic Substances List

  • Deletes these CAS numbers from Part I: 85711-46-2, 122055-81-6, 2768948-95-2.
  • Adds a long list of CAS numbers to Part I (the Canada Gazette publishes the full list). Examples include 112-87-8, 118-45-6, 611-99-4.
  • Adds two named substances to Part II:
    • 19787-5 — Alkenoic acid, telomer with sodium non-metallate, compd. with nitrilopoly[alkanol]
    • 19788-6 — Alkenoic acid, butyl ester, polymer with ethenylheteromonocycle, ester with methyl-hydroxypoly(substituted-ethanedisubstituted)
  • Replaces the masked name for 19637-5 with a full chemical description.
  • Comes into force on the day it was published in the Canada Gazette (September 20, 2025).

• Order 2025-87-09-02 Amending the Non-domestic Substances List

  • Deletes this CAS number from Part I: 25986-77-0.
  • Comes into force when Order 2025-87-09-01 Amending the Domestic Substances List comes into force (the Gazette notice does not give that date).

Who's affected#

• Manufacturers, importers, distributors and users of chemicals whose CAS numbers appear on these lists.
• Chemical suppliers and product formulators who need to track which substances are classified as non-domestic.
• Environmental consultants, labs, and compliance officers who advise businesses on federal chemical listing and reporting.
• The Gazette lists mostly CAS numbers; it is not always clear from the notice which everyday products or industries use each listed substance.

Why it matters#

• Changes to the Non-domestic Substances List are used by federal authorities to track and manage chemicals that are not on the Domestic Substances List. That influences which substances are subject to federal review, notification or other tracking programs.
• Businesses that make, import or use the listed substances may need to check the updated lists to understand any new reporting or assessment steps they should take.
• Because the Gazette item gives mostly CAS numbers, people and companies should look up the specific CAS numbers or consult a compliance advisor to see whether these changes touch their products or operations.