Non‑domestic Substances List Amended

Summary#

These notices announce two federal orders that change the Non‑domestic Substances List under the Canadian Environmental Protection Act, 1999. The main Order, Order 2025-66-01-02 Amending the Non-domestic Substances List, removes a few entries and adds a very large set of chemical identifiers; a second Order, Order 2025-87-09-02 Amending the Non-domestic Substances List, removes one entry because that substance was moved onto the Domestic Substances List. The Environment orders take effect on publication day unless the order says otherwise (the Canada Gazette entry was published September 20, 2025).

What it does#

• Order 2025-66-01-02 Amending the Non-domestic Substances List

  • Deletes the following CAS numbers from Part I of the list: 85711-46-2, 122055-81-6, 2768948-95-2.
  • Adds a very large number of substances (listed by CAS number) to Part I. The Canada Gazette prints the full list of identifiers; this summary does not reproduce them all.
  • Amends Part II by adding the entries 19787-5 and 19788-6 (each shown with its chemical name in the Gazette).
  • Replaces the masked name for 19637-5 in Part II with its full descriptive name.
  • States the Order comes into force on the day it is published in the Canada Gazette.

• Order 2025-87-09-02 Amending the Non-domestic Substances List

  • Deletes 25986-77-0 from Part I of the Non‑domestic Substances List because that substance was added to the Domestic Substances List by a related Order.
  • Says it comes into force on the day Order 2025-87-09-01 Amending the Domestic Substances List comes into force (so the exact effective date depends on that other order).

Who's affected#

• Manufacturers, importers and distributors of chemicals who track CAS numbers for regulatory reporting.
• Businesses that use or handle industrial chemicals, and their compliance teams.
• Environmental consultants, testing labs and consultants who prepare notifications or assessments under the Act.
• Provincial/territorial regulators and federal program staff who monitor chemical inventories and screening activities.
• Members of the public and community groups interested in which substances are being tracked by federal chemical lists.

If you use a specific CAS number, check the full Canada Gazette text or the public lists to see whether that exact identifier was added or removed.

Why it matters#

• Being on the Non‑domestic Substances List or the Domestic Substances List affects how a substance is tracked and considered under federal chemical management programs. Changes can change who must report, or which screening or assessment paths apply.
• The large addition of CAS numbers means many substances have been newly listed; that may trigger obligations for companies that import or manufacture them in Canada.
• The removal of a CAS because it was moved to the Domestic List signals the government now recognizes the substance as present domestically, which may lead to different oversight or follow-up actions.
• The notice itself is mostly a technical update to official lists. For specific consequences (reporting deadlines, required filings, or assessment status), affected parties should consult the full Order text and the Government of Canada chemical management guidance.